Online Catalog
A collection of nonclinical studies & assays; customization is possible.

OECD 422: Combined repeated dose toxicity study (w/screening)

The objectives of the Combined Repeated Dose Toxicity Study with the reproduction/developmental toxicity screening test are to examine chemical exposure on male and female reproductive performance, in addition to the standard requirements for Repeat Dose General Toxicity studies of 4-week duration (OECD 407). 

The study design is a combination of the OECD 421 test guideline and the OECD 407 test guideline and therefore adds additional endpoints including clinical pathology, full histopathology and neurobehavioral assessments.


Combined Repeated Dose Toxicity Study with the Reproduction/Development Toxicity Screening Test






Administration Routes

Dietary, Gavage

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