Online Catalog
A collection of nonclinical studies & assays; customization is possible.

OECD 452/OCSPP 870,41: Chronic toxicity studies

OECD 452/OCSPP 870,41: Chronic Toxicity studies provide guidance to establish the chronic effects of a test substance over 12 months of dose-response observations. Testing should be performed with two mammalian species - usually 40 rats and eight dogs - with at least three dose levels plus the control group, depending on the limit test result. Administration routes (oral, dermal or inhalation) depend on the toxicokinetic profile/physical characteristics of the test substance. Daily or weekly (more thorough) observation reports include animal weight, skin/fur evaluation and respiratory patterns. Blood counts, urinalysis, ophthalmological examinations, gross necropsy and histopathology are also performed.



Canine, Mini-pig, Mouse, Rat

Administration Routes

Dietary, Gavage

Industry Market

Chemical, Crop